Vesiculo-Bullous Lesions


Fitz-Patrick Classification

According to Anatomical Plane:


1. Intra-Epidermal Blisters


A. Granular Cell Layer
  • Pemphigus Foliaceous
  • Frictional Blisters
  • Staphylococcus Scalded Syndrome

B. Spinous Cell Layer
  • Eczematous Dermatitis
  • Blisters secondary to heat & cold
  • Herpes virus infection
  • Familial Benign Pemphigus

C. Suprabasal
  • Pemphigus Vulgaris
  • Pemphigus Vegetans
  • Darrier's Disease

D. Basal Layer
  • Erythema Multiforme
  • Toxic Epidermal Necrolysis
  • Lupus Erythematosus
  • Lichen Planes
  • Epidermolysis Bullosa Simplex

2. Dermal-Epidermal Junction Zone


A. Lamina Lucida
  • Bullous Pemphigoid
  • Cicatricial Pemphigoid
  • Epidermolysis Bullosa Junctional

B. Below Basal Lamina
  • Erythema Multiforme
  • Epidermolysis Bullosa Dystrophica